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If the problem is desire rather than mechanics, brain-acting peptides are the appropriate tool

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Ruggiero R, Mascolo A, Spezzaferri A, Carpentieri C, Torella D, Sportiello L, et al

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In a diverse array of animal and cell-based models of neurological disorders, semaglutide has exhibited distinct protective effects, providing a biological rationale for its exploration in human studies

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The latter one which included 4 trials (43,456 patients) suggested that GLP-1 RAs reduced MACE by 13% (HR 0.87, 95% CI 0.820.93), an effect which was consistent in both subgroups (HR 0.91, 95% CI 0.850.97 and HR 0.80, 95% CI 0.720.90 with and without metformin, respectively)

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